Anti-Spike ECD (SARS-CoV-2) monoclonal antibody (AT-ECD-35)
Synthetic human library
SARS-CoV-2 spike protein, S1 domain
Coronaviruses are enveloped positive-sense RNA viruses. The most prominent feature of coronaviruses is the club-shape spike projecting from the surface of the virion. Human coronaviruses, first identified in the mid-1960s, are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV), Severe Acute Respiratory Syndrome (SARS-CoV) and 2019 coronavirus disease (COVID-19), which was infected by SARS-CoV-2 virus and first reported from Wuhan, China, in 2019. The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Many studies have been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human angiotensin converting enzyme II (ACE2) receptor. The SARS-CoV spike (S) protein contains two subunits: the S1 subunit has a receptor binding domain (RBD) that interacting with host ACE2; the S2 subunit plays key parts in fusion between the viral and host cell membranes.