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Anti-Human ACE2 monoclonal antibody (AT-ACE2-2)

Key features:

  1. Monoclonal antibody from synthetic antibody libraries developed by AnTaimmu BioMed
  2. High affinity with spike (S) glycoprotein of SARS-COV-2
  3. Suitable for ELISA application
  4. IgG1 isotype

Datasheets   Contact us for MSDS

Description

Product name

Anti-Human ACE2 monoclonal antibody (AT-ACE2-2)

Catalog number

ATBM-A-19

Source

Synthetic human library

MW (kDa)

150 kDa

Isotype

Human IgG1

Species Reactivity

Human ACE-2 protein

General notes

Background Information

Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency. In addition, ACE2 C terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity. The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Many studies have been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human angiotensin converting enzyme II (ACE2) receptor. The SARS-CoV spike (S) protein contains two subunits: the S1 subunit has a receptor binding domain (RBD) that interacting with host ACE2.

Properties

Form

Liquid

Storage instructions

Store at 4°C for up to 1 months from date of receipt. For long term storage, aliquot and store at -20°C. Avoid freeze-thaw cycles

Storage buffer

1 x PBS

Purification

Affinity purified by protein A

Contains

N/A

Conjugate

Unconjugated

Clonality

Monoclonal

Validated Applications

Applications Dilution
ELISA 1:1000~1:10000

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REFERENCES

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